05 June 2015
Scientists, don't talk down to the the public
08 May 2014
Open Letter to the City University of New York
30 April 2013
Being Settled Can Be Unsettling
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| A recent find while hiking in tropical Central America |
Some 15 years ago, I went to talk to Michael Balick at the NYBG when I was thinking about going back to school to study Ethnobotany. I told him what I was thinking about, and I think he was looking for all kinds of ways to discourage me from the field. One question he did ask that has stuck with me was, "Imagine yourself in 10-15 years, and where you'd like to be working and what you could see yourself doing."
Interestingly, my first though was that I wanted to have a lab and greenhouses and gardens.
I had decided that I wanted to study Ethnobotany because I loved plants, the tropics, and was fascinated by the use of plant chemistry. Later as I got into school, I came to realize that I was less keen on being an anthropologist. Around the same time, I became a father and got an NIH award for a phytochemisty project - both those things made it harder to take of for months at a time to the forests of the Western Ghats (where I wanted to do fieldwork). And so that secured my place behind the bench, running columns, HPLC, doing MS/MS experiments, and trying to get the best shim out of our 300 MHz NMR so that I could try to get carbons on a couple mgs of sample.
But I also worked in the greenhouse as a grad student. I think about Balick's question at the time, but I had my lab and my greenhouse. And many years later, after a molecular pharmacology postdoc, I've got my industry job as a phytochemist. I like to say I'm the only botanist in the company. And one of the few who might claim some sort of natural products chemistry background. And again I have my own lab (I wish I had postdocs or other help) and a large garden plot on site. No greenhouse (yet), but I do have lights set
up in my lab to start seeds and keep some tropical plants happy through the winter months. A little soil on the counter top of one bench isn't going to bother anyone but me, after all.So here I am, with what should be a dream job. And in a lot of ways it is. But there's still something unsettling about being "settled" for me. My wanderlust is always there, the attraction to the field, the place where all that botany and chemistry originates. It's the set and setting that makes the magic of science come to life, I think.
11 March 2013
Cheminformatics, here I come
06 March 2013
You knew that when you contacted me
So I accepted his invitation, and he sent me another email describing an interest in a fruit that I had studied. I had published a paper or tow on the phytochemistry of this fruit, and he wanted to talk to me about it. OK, why not..? The last time I followed up on a query like that, I'd gotten some delicious juice and jam made from the fruit in question from someone who was grateful for some information (he was starting a company marketing products from a related fruit.)
So I found a time when I was free and called him up to see what it was he wanted. I thought he had some questions about the beneficial phytochemistry. But it seemed more like he just wanted to talk about the fruit, and never really got around to asking any questions. Mostly, he told me about what he was working on, which was totally unrelated to my current research interests.When I tried to ask him about how he managed his agreements to collect and "sustainably harvest" material from Brazil, I got some vague answers about knowing everyone and having worked there for decades. It's not the sort of guarantee I would rely on if I was afraid of biopiracy claims.
It took a while, but I managed to eventually get off the phone. He wanted to send me some samples "to test," even though I know it wouldn't go anywhere in my current program, and I lately I've been a stickler for making sure any plant material that goes into my research needs to be verified as ethically sourced.
Anyway, I wasn't surprised when I never got a package, but I was a little surprised today when I got another email, and he makes it sound as if I'm some back-handed evil monster. I didn't even want his wingnut crap.
From his email:
I'm very concerned about dealing with 'Big Guy's" for fear of being scooped up and piled on the heap of entrepreneurial road kill once a large multi national get's their hands on people like me. Nothing personal, but I have spent 20+ years doing what I do and about to launch a product in a week and clinical trials soon after.
Ouch, dude. It is sorta personal. You came to me, sought me out, and used one of my mentor's names to get me to respond. And then you make it seem like I'm trying to gobble up your precious invention. Um, OK. I guess we can all breath a sigh of relief now.
SciFinder playing some Natural Products love
27 February 2013
Scifinder highlights Natural Products Chemistry in short video
09 August 2011
Life Beyond Academia
So wrapped up in my new life. I originally wrote this post back in March when I first started the new job, but then I thought I’d finish it up… And the next thing you know, months have gone by.
Change is good. Generally I've embraced that, but as we get older and more set in our ways, it gets harder... But now I'm plunging headlong into all kinds of change. It makes me smile, to tell the truth. It feels good, even though it feels like this sort of change is so much more drastic now - it's not just about me anymore...
In January, I was hitting the 4-year mark on a somewhat productive postdoc. Having "grown up" through the academic ranks, I was actually feeling like I was finally overcoming a stagnation in my research, and was making some interesting inroads. I had funding and got along well with my PI and collaborators, but was certainly becoming disillusioned by the academic prospects. If you read earlier posts, you'll get a sense of this, I'm sure. And then a job opening came my way via a friend in the field. Good timing.
I got the offer, and took the job, and now I'm working in a large company. One of the biggest, in fact. And I've left cancer pharmacology to work on "products." I never imagined that in a million years. And even writing those words is a bit hard. I'm altruistic, idealistic, and against gross consumerism. I want to do good, I dream of anarchist utopias. And now I'm working for the man. And yet, nothing about it feels like "selling out." Is that another indicator that I'm getting old, caving on my principles? I really don't think so. I still feel like me. And I honestly think that they hired me so I could continue to be me. I stepped into this whole thing feeling pretty blind. When people asked me what I’d be doing, I honestly had to say I really didn’t know. During the interview, when I asked what I’d be doing day-to-day, I got a long non-specific answer that basically meant, “We want you to come here and be a part of the team. And you’re smart enough to figure out what you have to offer.”
I never knew that consumer products could be so science-driven. R&D really rocks it here, bringing new ideas to the rest of the company. And the science is real. Not fake claims just for labels. There is a real desire to be able to stand behind the efficacy and safety.
And the thing that has been really great is seeing how crucial it is that everyone is collaborative. And the ability to think in multiple ways, to be an interdisciplinarian make sense. Unlike academia, you can’t simply hide out in your own lab, working diligently away at your own project, ignoring everyone else, with an eye to papers, funding, and building your own personal empire of postdocs, students, and technicians. You won’t get anywhere in industry that way. What a relief!
Now it seems to me that the academy doesn't actually practice all that it preaches when it comes to things like research freedoms, the importance of multidisciplinary scientists, appreciation of radical thinking, etc. And industry (at least the company where I am) sees these things as vital to growth, innovation, and success. I’ve been a bench scientist for the last 11 years. Hands-on experimentalist. If I want to isolate a compound, figure out the chemical structure, work out the botanical chemotaxonomy, or see how a cancer cell responds to that compound, I essentially had only myself to rely on to get that work done. Now, if I can’t find someone on the team to help with a problem, then I look outside. And we can collaborate with anyone…
So far so good. I am getting to be a scientist in all sorts of ways, and I have to apply things I've learned in other parts of my life. It makes it seriously challenging and quite varied and more fun than I ever expected... Anyway, those are my impressions for now. More to come.
19 May 2011
An aromatic progression of flowering trees of NYC
26 February 2011
A few of my favorite (phyto)chemical things
1. Realizing that the compound you finally isolated is, in fact, new
2. Realizing that your new compound is bioactive
3. Discovering that someone has synthesized a compound you discovered
4. Sephadex LH-20: the best stationary phase ever
5. Seeing liquid oxygen condension out of the atmosphere and dripping off the liquid helium port when doing a cryo fill for the NMR
6. Plant collection trips
7. Ion traps that fragment a compound just right & accurate mass when you need it.
8. Butanol and toluene when you need to evap water faster
9. Getting the solvent system right the first time - and nailing the pure compounds.
10. Training on a 300 MHz, and then moving on to a 500
11. a new HPLC column
12. fixing my own glassware
25 February 2011
Untangling the web
I was hoping to be done by the end of the day today, but now, at 3:30, it's not looking like I'll manage that. I've found all my raw electronic data from the various other labs and core facilities and copied it onto a harddrive. I've backed-up all my data from inside the lab. Cleaned out my bench, my desk, the -20 & -70 freezers, cold room, refrigerators, tissue culture room, etc. I've given away all the little goodies I've collected over the years, passed out primers, solutions, media, etc. I've put away all my specialized glassware, & even created several new storage drawers for stuff I used and no one else will use. Passed on passwords and given lessons in HPLC maintenance/operation. Written up (most) of the new protocols I brought to lab....
But I still need to label a few thigns that will go into storage. And write up materials and methods sections for 2 papers and hand off all the data, samples, and papers for my 2 main projects. Write a review paper (oy..)
But I'm close, so close. The faster I finish, the more time I'll have before starting my new job to relax a bit. And I need that...
17 February 2011
My million dollar training
So tonight, as I was coming home from the lab, I started thinking about all the money that the government has invested in my training as a scientist. Right now, I'm wrapping up my 4-year postdoc and about to move into industry. I've basically spent the last 11 years doing cancer research on the government dime, and now I'm going to take all that training and head into the private sector to work on something totally different. I can honestly say that the most recent election provided the final nails to hammer shut the coffin wherein I buried any last vestiges of a career in academia-based research. Not only are conservatives anti-science, but I think they're simply anti-education as well. They have enough money, apparently, to pay people to educate their children, so public education be damned. The part I can't understand is that they'll still get cancer at the same rate as everyone else, so by denying science, they aren't helping themselves...
But aside from all that, let's get down to numbers. My F32 fellowship: $150,000; T32 postdoc fellowship: $125,000; DoD postdoc fellowship $380,250. Then there was my heavily subsidized Public Univ tuition, which was paid in full by university fellowships before my F32, the salary I got as an adjunct lecturer as a grad student, and even some subsidized student loans... All told, we're looking at close to a million dollars, maybe. And that doesn't include the salaries of my professors at the Public Univ, or any of the Public Univ infrastructure that public funds supported. I'm mostly just thinking about money that went to supporting me, my family, and my research directly.
That's quite an investment. You would think that the country would want to keep me working on cancer pharmacology. After all, I know a lot more about it than when I started 11 years ago. Way more. In fact, I feel like I'm actually getting to the point where I could make some real contributions... But instead, the private sector is benefiting from all that public investment. The company I'm going to work for is getting a bargain. They can pay me well, but they're getting a trained scientist for their money. The US taxpayer, however, is losing my expertise. I'm off to make products!
14 February 2011
Good-bye Cruel World!
23 January 2011
What's next?
For the most part, I've been had the mindset that I would naturally follow the grad student-postdoc-assist prof track and settle into being a PI somewhere. Since I already live in NYC with kids, I was hoping that it would be here. I love this place, and have had a hard time imagining leaving... But I always knew that at some point, I would likely have to make some decisions about the Big Apple.
After being totally frustrated with the process of applying for jobs (see here), this past Fall, I took one or two looks at the list I made of positions I planned to apply for, and quietly set it underneath a stack of papers to be read, which were under notes from seminars and my lab notebook. I just didn't have it in me. In addition, I am lucky enough to have my own funding, which is good for another (almost) 2 years. So instead of sending out applications, I decided that I should really focus on getting out a couple publications.
In my mind, I imagined a scenario where I submitted my K99 at the end of 2011, and it came through just as my current funding ended in fall of 2012... or even a little earlier. Then I would be applying for academic jobs in the Fall 2012 with that in my pocket. It wouldn't necessarily guarantee that a job would open up in NYC, but at least it would give me a big boost when applying for jobs. But then, of course, the most obvious wrinkle in the plan is the possibility of not winning the K99....
Either way, I'd still be a postdoc going into debt living in NYC for far too long.
So when a friend emailed my a job listing for a position that described me fairly well in Industry (HUGE industry), I said "what the hell" and sent a CV. In my experience, Industry does not call back unless someone on the inside hands your CV to the person in charge of hiring; I didn't expect any response. But then the strange things started happening. They emailed back. The next day. And wanted a phone interview 2 days later. The phone interview went well, & I could tell they were planning to ask me in for a visit. Which they did - within a week.
The day of interviews started off with a 30 min Powerpoint presentation, where I tried to summarize 10 years of research on various projects into an interesting cohesive story. Then I met with several people, all of whom were super nice and seemed to be trying to persuade me more than I was trying to persuade them. And I liked them. I liked what they were doing. And I told them so...
And on the train back to the City, I got a call on my mobile that the consensus was positive, and HR would call me very soon. And now, after a few more phone calls, I'm waiting to see what the "offer" will look like... and have just told our 9-yr old about the possibility of leaving the City (more on that later).
I'm a little dumb-founded by it all. The speed, the new directions, the possibility of getting out of debt and making a radical change in life. My current PI is nice enough about it, but I don't think she likes the idea of me leaving academia. Neither does my former thesis adviser. It's like I'm turning my back on them. I can go on and on about this point, but I won't right now. If I end up taking the job, then I'll write all about my feelings on why and how it came to this... for now, I'm just going to say, I hope they make me an offer I can't refuse, because academia is getting on my nerves a little right now.
13 December 2010
Glut of Scientists?
See Beryl Lieff Benderly's article The Real Science Gap at Miller-McClune.
Update:
Another piece in the Economist on this topic here.
22 November 2010
Dear Academic Search Committee
The Red Wave of Anti-Science
But as I watched the election map turn red on Tuesday night, I couldn’t avoid the sinking feeling that my own job was being threatened. And not only my job, my livelihood, and everything that I’ve worked for over the last dozen years, I think it threatens your personal health. Not just because the Republicans want to overturn “Obamacare.” The problem is the apparent disregard for science in the conservative camp. I have a Ph.D. and work as a cancer pharmacologist at major medical school. But my research and salary are paid for by Federal grants. So between the Republican distain for science, education funding, and the use of embryonic stem cells in research, the red map is truly scary.
When I began grad school, the NIH budget was in a period of increasing funding. Then under the second Bush Adminsitration, the NIH budget plateaued. In real dollars, it registered as a budget squeeze. Funding became tighter, and grants became more competitive. The average age of the first-time grant winner increased into the mid-forties. With research dollars disappearing, and education funding in decline, tenure-track positions began disappearing along with postdoctoral and grad school slots. Everyone has had to tighten their belts.
And if budgetary concerns aren’t enough, it became obvious during the Bush years that politics will trump good science. Regardless of field of research we’re engaged in – the effect has been noticed and felt by all scientists. Data from climatologists and environmental scientists has been the most obvious examples in the media. EPA, FDA, and USDA scientists have described pressure to change or suppress results that conflicted with Bush polices. And for me and many in biomedical research, there’s the stem cell issue. Stem cells open up so many possibilities in biomedical science, I can’t describe them all here.
I’m afraid that students in our schools are gorwing up scientifically illiterate. Kids are naturally curious, ready to engage the world. Without classrooms that nurture that love of experimentation and exploration, or that teach kids critical thinking, we will be looking at a dearth of invention and innovation in America. And we’ll be faced with a generation who can’t distinguish between the “theory” of intelligent design and the theory of evolution. And America will not evolve intelligently.
[Note: originally published Nov 8, 2010 @ http://bike-nyc.blogspot.com/2010/11/red-wave-of-anti-science.html]
Why are Modern Scientists So Dull?
He then followed it up this year with another in the same vein Why it is ‘better’ to be reliable but dumb than smart but slapdash: Are intelligence (IQ) and Conscientiousness best regarded as gifts or virtues
It's funny, though, because while I do see creativity hammered out of people by schools, from elementary all the way up to graduate school, I have always felt that academia protects socially-inept misanthropes - they are given far too much leeway to be stupid annoying people because pehaps that somehow is the mark of real genius...
[Note: originally published Oct 6, 2009@ http://bike-nyc.blogspot.com/2009/10/dumb-and-dumber-science.html]
